Monday, March 13, 2006

Human+


(The above image is of Desire, the hermaphroditic demiurge from Neil Gaiman's The Sandman series.)

The fact that humanity is not so binary as XX/XY is, by now, not an entirely esoteric notion, but did you know just how fascinating certain intersexual conditions can be? Some of these conditions can be pretty similar in that they just involve a general underdifferentiation of the sexes, but others can be rather wild indeed.

Here are some of the 'greatest hits' of intersexual genetic disorders:

Triple-X Syndrome
Women affected with this disorder are otherwise normal women, albeit unusually tall and of slightly more androgynous appearance. These women are more athletic and can typically conceive children normally. Five to ten of these women are born every day in the US, or about 1 in 1000. I think that's more than enough to keep the WNBA in business.

XYY Male Syndrome
Even more common than their counterparts, at 1 in 850 are these men who are extra manly. They are taller than average and generally taller than their fathers, suffer from severe acne, have large hands and feet, and more likely to end up in prison (possibly due to their especially aggressive nature).

Mosaicism
Mosaicism is not a specific disorder, but a phenomena that causes a human to have cells with extra chromosones in them. This can allow an individual to possess both XX and XY reproductive cells. Its potential for genetic engineering makes this almost-chimerism especially proocative.

Androgen Insensitivity Syndrome
A couple of weeks ago, a certain doctor proclaimed that "the perfect woman is a man." This, of couse, only applies to the relatively less common Compliete Androgen Insensitivity Syndrome, or CAIS. General AIS has a variety of manifestations that are more or less typical of intersexed individuals, but CAIS results in a very unusual case. The male affected will grow testes, but will also be immune to the masculinizing effects of testosterone. This testosterone will have an effect on the the now otherwise completely female development, however, and no female reproductive organs will develop - though a normal, if sometimes shallow, vagina will form. The testosterone will also produce full breasts at the male's puberty, though he will never grow substantial body hair. This man will, in effect, be a hyperfemine, normally functional, but sterile, woman. A genetically male individual of pure estrogen. Incidence is 1 in 20,000, which means that anyone who has left their village recently is sure to have seen at least a few such individuals.

Stella Tennant
Characterized by extreme hotness. Genetic composition unknown.

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